Another +1 for Photopea from me. I had been on-and-off wrestling with Wine to get Photoshop to run since I had switched to Linux, but since discovering Photopea I haven't felt the need to bother with that. In addition to the website version, if you aren't religiously anti-Electron, there's a desktop app for it on Flathub.
I'm not really using "vanilla" GNOME since I have a number of extensions, but the only one that really modifies the workflow is Tray Icons: Reloaded.
That said, while it's definitely not for everyone, I'm very comfortable with it. I like that everything feels "out of my way" unless I need it, and I find the Activities view to be easier for finding a minimized program at a glance than a taskbar.
Another +1 for Photopea from me. I had been on-and-off wrestling with Wine to get Photoshop to run since I had switched to Linux, but since discovering Photopea I haven't felt the need to bother with that. In addition to the website version, if you aren't religiously anti-Electron, there's a desktop app for it on Flathub.