Thanks everyone for your replies, I’m really interested in KDE Plasma now.
I agree that KDE Plasma should satiate your desire for customizing the look and feel of your system. But, note that KDE Plasma isn't properly supported on Linux Mint. Therefore, consider switching to a Distro in which it is; e.g. the KDE Flavors/Spins of Fedora, openSUSE or Ubuntu.
Consider mentioning the programs you work with. On a general note, Wine can be used to make Windows-software work on Linux. Bottles can be used to that effect as a front-end. Furthermore, for a more sophisticated solution; consider taking a look at CodeWeavers.