When Retro-bit announced their licensing partnership with Sega, I was really excited. I got their first wave Saturn USB pad, and I now have a Big 6 that combined a 6-button pad with the style of the 3-button Genesis pad. Still waiting for that dual analog variant they promised though...
It was around the same time I think that Retro Fighters came out with a new original port Dreamcast controller, the Striker. Awesome controller. I got a Raphnet adapter just to use it on pc from time to time.
Then there's the arcade stick I custom built for the specific purpose of authentic arcade gaming at home. Uses a Suzo Happ lever (even though they used to be made by Industrias Lorenzo), and Industrias Lorenzo buttons.
If a don't need an analog stick, my go-to has been the Hori Fighting Commander Octa. It has a stick, but I don't use it often. The buttons are microswitched and it feels great.
If I do need the sticks, Series X controllers are fine, generally.
Update: Last Stand is there, comes with all the DLC gear, but does not carry over character progress from Steam (not that I expected it to). Just, you know, a heads up if you spent a few dozen hours triple prestiging every hero.
However, I'm dubious if it actually connects to any servers, matchmaking or otherwise. From the main lobby it shows I am the only player in General, where everyone online would be. Aaaaand nobody but me. Surely some other weirdo besides me is playing the game during daylight hours on GOG.
While not a straight ready-to-go port....exactly, I was really impressed by DeltaTouch and QuadTouch. It ports over a bunch of id software sourceports to Android making it possible to play not only Doom, Heretic, and Strife, but Quake and Hexen II - most with mod and controller support.
There is a little bit of prep involved - eg. you still need legal copies of stuff, and you will need to move files around on your device, but otherwise not bad.
You might be thinking Sega CD, which had re-releases of Ecco, but not the 32X.